Version 5.4
Homo sapiens Gene: NUP85
Summary
InnateDB Gene IDBG-68125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP85
Gene Name nucleoporin 85kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125450
Encoded Proteins
IDBP-68127
nucleoporin 85kDa
IDBP-590454
nucleoporin 85kDa
IDBP-764309
IDBP-761563
IDBP-762318
IDBP-760706
IDBP-758480
IDBP-764221
IDBP-759528
IDBP-758494
IDBP-763782
IDBP-761521
IDBP-760187
IDBP-764207
IDBP-759166
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75205659-75235758
Strand Forward strand
Band q25.1
Transcripts
ENST00000245544 ENSP00000245544
ENST00000449421
ENST00000540768 ENSP00000445855
ENST00000577645
ENST00000582681
ENST00000579838 ENSP00000462364
ENST00000583548
ENST00000583070 ENSP00000463542
ENST00000579298 ENSP00000462749
ENST00000581335
ENST00000583877 ENSP00000463715
ENST00000579324 ENSP00000463382
ENST00000579557 ENSP00000463496
ENST00000581104 ENSP00000461919
ENST00000578830 ENSP00000462920
ENST00000578987 ENSP00000464544
ENST00000580879 ENSP00000463377
ENST00000584155 ENSP00000464433
ENST00000583948
ENST00000579900 ENSP00000463437
ENST00000577561
ENST00000578294
ENST00000583569 ENSP00000462487
ENST00000577208
ENST00000582833
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0006935 chemotaxis
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0030032 lamellipodium assembly
GO:0044281 small molecule metabolic process
GO:0048246 macrophage chemotaxis
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005635 nuclear envelope
GO:0005819 spindle
GO:0005829 cytosol
GO:0016020 membrane
GO:0031080 nuclear pore outer ring
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020739
View Gene Order
ENSBTAG00000016126
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_6804
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6167
Influenza Infection pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_25229
Interferon Signaling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_1275
Mitotic Anaphase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6145
Influenza Life Cycle pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.362817
RefSeq NM_024844 XM_005257692 XM_005257693 XM_006722094
HUGO
OMIM
CCDS CCDS32730
HPRD 01363
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca