Homo sapiens Gene: LLGL2
Summary
InnateDB Gene IDBG-68503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LLGL2
Gene Name lethal giant larvae homolog 2 (Drosophila)
Synonyms HGL; LGL2;
Species Homo sapiens
Ensembl Gene ENSG00000073350
Encoded Proteins
lethal giant larvae homolog 2 (Drosophila)
lethal giant larvae homolog 2 (Drosophila)
lethal giant larvae homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein\'s ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75525080-75575208
Strand Forward strand
Band q25.1
Transcripts
ENST00000375227 ENSP00000364375
ENST00000167462 ENSP00000167462
ENST00000392550 ENSP00000376333
ENST00000545227
ENST00000577211
ENST00000577200 ENSP00000464397
ENST00000578363 ENSP00000464603
ENST00000582860
ENST00000580925 ENSP00000461953
ENST00000578034
ENST00000578638 ENSP00000463501
ENST00000579092
ENST00000577500
ENST00000583514 ENSP00000462439
ENST00000578719 ENSP00000463150
ENST00000580027
ENST00000581713 ENSP00000463390
ENST00000583658 ENSP00000464483
ENST00000578536 ENSP00000464451
ENST00000580578 ENSP00000464598
ENST00000579392 ENSP00000463721
ENST00000582393
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
Experimentally validated
Total 300 [view]
Protein-Protein 300 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006887 exocytosis
GO:0007049 cell cycle
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KRE1 J3QLV4
UniProt Splice Variant
Entrez Gene 3993
UniGene Hs.514477
RefSeq NM_001015002 NM_001031803 NM_004524 XM_006721897 XM_006721898 XM_006721899
HUGO HGNC:6629
OMIM
CCDS CCDS11725 CCDS32733 CCDS45776
HPRD 10041
IMGT
EMBL AC100787
GenPept
RNA Seq Atlas 3993