Homo sapiens Protein: LLGL2
Summary
InnateDB Protein IDBP-245434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LLGL2
Protein Name lethal giant larvae homolog 2 (Drosophila)
Synonyms HGL; LGL2;
Species Homo sapiens
Ensembl Protein ENSP00000376333
InnateDB Gene IDBG-68503 (LLGL2)
Protein Structure
UniProt Annotation
Function Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269PubMed:15632202}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
Experimentally validated
Total 300 [view]
Protein-Protein 300 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006887 exocytosis
GO:0007049 cell cycle
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000664 Lethal(2) giant larvae protein
IPR001680 WD40 repeat
IPR013577 Lethal giant larvae homologue 2
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PF08366
PRINTS PR00962
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1M3
PhosphoSite PhosphoSite-Q6P1M3
TrEMBL J3QSA6
UniProt Splice Variant
Entrez Gene 3993
UniGene Hs.514477
RefSeq NP_001026973
HUGO HGNC:6629
OMIM
CCDS CCDS32733
HPRD 10041
IMGT
EMBL AC100787 BC006503 BC010879 BC064994 X87342
GenPept AAH06503 AAH10879 AAH64994 CAA60780