InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CEP57

Summary

InnateDB Gene

IDBG-68511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEP57

Gene Name

centrosomal protein 57kDa

Synonyms

MVA2; PIG8; TSP57

Species

Homo sapiens

Ensembl Gene

ENSG00000166037

Encoded Proteins

IDBP-68513

centrosomal protein 57kDa

IDBP-68515

centrosomal protein 57kDa

IDBP-597500

centrosomal protein 57kDa

IDBP-588491

centrosomal protein 57kDa

IDBP-584324

centrosomal protein 57kDa

IDBP-603628

centrosomal protein 57kDa

IDBP-591715

centrosomal protein 57kDa

IDBP-595175

centrosomal protein 57kDa

IDBP-596809

centrosomal protein 57kDa

IDBP-594750

centrosomal protein 57kDa

IDBP-590289

centrosomal protein 57kDa

IDBP-597234

centrosomal protein 57kDa

IDBP-585402

centrosomal protein 57kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95789965-95832693

Strand

Forward strand

Band

q21

Transcripts

ENST00000325542	ENSP00000317902
ENST00000325486	ENSP00000317487
ENST00000537677	ENSP00000441392
ENST00000538095	ENSP00000443866
ENST00000544522	ENSP00000438065
ENST00000539855	ENSP00000437422
ENST00000541365	ENSP00000445821
ENST00000535497	ENSP00000442481
ENST00000540830	ENSP00000440996
ENST00000538658	ENSP00000445706
ENST00000536587
ENST00000541768
ENST00000537093	ENSP00000444749
ENST00000535224	ENSP00000440256
ENST00000538158
ENST00000541150	ENSP00000443436

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.

Experimentally validated
Total	102 [view]
Protein-Protein	99 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017134	fibroblast growth factor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007286	spermatid development
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034453	microtubule anchoring
GO:0051260	protein homooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton