Homo sapiens Gene: TMEM123
Summary
InnateDB Gene IDBG-69084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM123
Gene Name transmembrane protein 123
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152558
Encoded Proteins
transmembrane protein 123
transmembrane protein 123
transmembrane protein 123
transmembrane protein 123
transmembrane protein 123
transmembrane protein 123
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102396332-102470384
Strand Reverse strand
Band q22.2
Transcripts
ENST00000361236 ENSP00000355285
ENST00000398136 ENSP00000381204
ENST00000532161 ENSP00000435331
ENST00000528969 ENSP00000434976
ENST00000529492
ENST00000525577
ENST00000531103 ENSP00000433695
ENST00000526676 ENSP00000435842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
Biological Process
GO:0070267 oncosis
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL E9PSB1
UniProt Splice Variant
Entrez Gene 114908
UniGene Hs.503709 Hs.644378 Hs.737611 Hs.742016
RefSeq NM_052932
HUGO HGNC:30138
OMIM 606356
CCDS CCDS41702
HPRD
IMGT
EMBL AP000942 AP001830
GenPept
RNA Seq Atlas 114908