Homo sapiens Gene: MMP8 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-69164.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MMP8 | ||||||||||||||||||
Gene Name | matrix metallopeptidase 8 (neutrophil collagenase) | ||||||||||||||||||
Synonyms | CLG1; HNC; MMP-8; PMNL-CL | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000118113 | ||||||||||||||||||
Encoded Proteins |
matrix metallopeptidase 8 (neutrophil collagenase)
matrix metallopeptidase 8 (neutrophil collagenase)
matrix metallopeptidase 8 (neutrophil collagenase)
matrix metallopeptidase 8 (neutrophil collagenase)
matrix metallopeptidase 8 (neutrophil collagenase)
matrix metallopeptidase 8 (neutrophil collagenase)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 11:102711795-102727050 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q22.2 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Activation of Matrix Metalloproteinases pathway
Collagen degradation pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | E9PJB3 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 4317 | ||||||||||||||||||
UniGene | Hs.161839 | ||||||||||||||||||
RefSeq | NM_002424 XM_006718841 | ||||||||||||||||||
HUGO | HGNC:7175 | ||||||||||||||||||
OMIM | 120355 | ||||||||||||||||||
CCDS | CCDS8320 | ||||||||||||||||||
HPRD | 00385 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AP000647 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 4317 | ||||||||||||||||||