Homo sapiens Gene: GALR2
Summary
InnateDB Gene IDBG-69355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GALR2
Gene Name galanin receptor 2
Synonyms GAL2-R; GALNR2; GALR-2;
Species Homo sapiens
Ensembl Gene ENSG00000182687
Encoded Proteins
galanin receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:76074794-76077541
Strand Forward strand
Band q25.1
Transcripts
ENST00000329003 ENSP00000329684
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004966 galanin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
Biological Process
GO:0006936 muscle contraction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0007275 multicellular organismal development
GO:0007586 digestion
GO:0007611 learning or memory
GO:0007631 feeding behavior
GO:0031175 neuron projection development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43603
TrEMBL
UniProt Splice Variant
Entrez Gene 8811
UniGene Hs.666366
RefSeq NM_003857
HUGO HGNC:4133
OMIM 603691
CCDS CCDS11739
HPRD
IMGT
EMBL AF040630 AF042782 AF058762 AF080586 BC069130 BC074914 BC074915 BC109051 BC109052 CH471099 EF577401
GenPept AAC18118 AAC36587 AAC39634 AAD08671 AAH69130 AAH74914 AAH74915 AAI09052 AAI09053 ABQ52421 EAW89364
RNA Seq Atlas 8811