Homo sapiens Gene: UGGT1
Summary
InnateDB Gene IDBG-69471.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGGT1
Gene Name UDP-glucose glycoprotein glucosyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136731
Encoded Proteins
UDP-glucose glycoprotein glucosyltransferase 1
UDP-glucose glycoprotein glucosyltransferase 1
UDP-glucose glycoprotein glucosyltransferase 1
UDP-glucose glycoprotein glucosyltransferase 1
UDP-glucose glycoprotein glucosyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:128091200-128195677
Strand Forward strand
Band q14.3
Transcripts
ENST00000376723 ENSP00000365913
ENST00000259253 ENSP00000259253
ENST00000430075 ENSP00000400426
ENST00000438277 ENSP00000392701
ENST00000418197 ENSP00000389441
ENST00000488439
ENST00000465836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006486 protein glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0097359 UDP-glucosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Calnexin/calreticulin cycle pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
ER Quality Control Compartment (ERQC) pathway
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Er associated degradation (erad) pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F8WCI2
UniProt Splice Variant
Entrez Gene 56886
UniGene Hs.623714 Hs.743306
RefSeq NM_020120 XM_006712634 XM_006712636
HUGO HGNC:15663
OMIM 605897
CCDS CCDS2154
HPRD 12064
IMGT
EMBL AC017079 AC108059
GenPept
RNA Seq Atlas 56886