Version 5.4
Homo sapiens Gene: UGGT1
Summary
InnateDB Gene IDBG-69471.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGGT1
Gene Name UDP-glucose glycoprotein glucosyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136731
Encoded Proteins
IDBP-43213
UDP-glucose glycoprotein glucosyltransferase 1
IDBP-69475
UDP-glucose glycoprotein glucosyltransferase 1
IDBP-385746
UDP-glucose glycoprotein glucosyltransferase 1
IDBP-385747
UDP-glucose glycoprotein glucosyltransferase 1
IDBP-385765
UDP-glucose glycoprotein glucosyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:128091200-128195677
Strand Forward strand
Band q14.3
Transcripts
ENST00000376723 ENSP00000365913
ENST00000259253 ENSP00000259253
ENST00000430075 ENSP00000400426
ENST00000438277 ENSP00000392701
ENST00000418197 ENSP00000389441
ENST00000488439
ENST00000465836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006486 protein glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0097359 UDP-glucosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037470
View Gene Order
ENSBTAG00000005444
Not yet available
Pathways
NETPATH
REACTOME
REACT_25091
ER Quality Control Compartment (ERQC) pathway
REACT_23810
Calnexin/calreticulin cycle pathway
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56886
UniGene Hs.623714 Hs.743306
RefSeq NM_020120 XM_006712634 XM_006712636
HUGO HGNC:15663
OMIM 605897
CCDS CCDS2154
HPRD 12064
IMGT
EMBL
GenPept
RNA Seq Atlas 56886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca