Homo sapiens Gene: FCAR
Summary
InnateDB Gene IDBG-69662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCAR
Gene Name Fc fragment of IgA, receptor for
Synonyms CD89
Species Homo sapiens
Ensembl Gene ENSG00000186431
Encoded Proteins
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Fc fragment of IgA, receptor for
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54874248-54890472
Strand Forward strand
Band q13.42
Transcripts
ENST00000355524 ENSP00000347714
ENST00000359272 ENSP00000352218
ENST00000345937 ENSP00000338257
ENST00000353758 ENSP00000338058
ENST00000391726 ENSP00000375606
ENST00000391725 ENSP00000375605
ENST00000391724 ENSP00000375604
ENST00000391723 ENSP00000375603
ENST00000469767 ENSP00000473814
ENST00000472634
ENST00000488066 ENSP00000474512
ENST00000482092
ENST00000471750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019862 IgA binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
RANKL pathway
REACTOME
KEGG
Staphylococcus aureus infection pathway
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.659872
RefSeq NM_002000 NM_133269 NM_133271 NM_133272 NM_133273 NM_133274 NM_133277 NM_133278 NM_133279
HUGO
OMIM
CCDS CCDS12907 CCDS12908 CCDS12909 CCDS12910 CCDS42622 CCDS42623 CCDS42624 CCDS42625 CCDS46180
HPRD 00914
IMGT
EMBL
GenPept
RNA Seq Atlas