InnateDB Protein
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IDBP-69666.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FCAR
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Protein Name
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Fc fragment of IgA, receptor for
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Synonyms
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CD89;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352218
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InnateDB Gene
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IDBG-69662 (FCAR)
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Protein Structure
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Function |
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. {ECO:0000269PubMed:12768205}.
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Subcellular Localization |
Isoform A.1: Cell membrane; Single-pass type I membrane protein.Isoform A.2: Cell membrane; Single-pass type I membrane protein.Isoform A.3: Cell membrane; Single-pass type I membrane protein.Isoform B: Secreted.Isoform B-delta-S2: Secreted.
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Disease Associations |
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Tissue Specificity |
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. {ECO:0000269PubMed:8666819, ECO:0000269PubMed:8836118}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
P24071
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PhosphoSite |
PhosphoSite-P24071
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TrEMBL |
A5Y2F0
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UniProt Splice Variant |
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Entrez Gene |
2204
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UniGene |
Hs.659872
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RefSeq |
NP_579806
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HUGO |
HGNC:3608
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OMIM |
147045
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CCDS |
CCDS12909
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HPRD |
00914
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IMGT |
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EMBL |
AC011501
BC027953
D87853
D87854
D87855
D87856
D87857
D87859
D87861
D87862
DQ075334
DQ075335
DQ075336
DQ075337
DQ075338
DQ075339
EF077232
S82919
U43677
U43774
U56236
U56237
X54150
X87765
X87766
X87767
X87768
X87769
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GenPept |
AAB00566
AAB00567
AAC50595
AAC50639
AAD14421
AAH27953
AAZ76577
AAZ76578
AAZ76579
AAZ76580
AAZ76581
AAZ76582
ABO30566
BAA13471
BAA13472
BAA13473
BAA13474
BAA13475
BAA13477
BAA13479
BAA13480
CAA38089
CAA61039
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