Version 5.4
Homo sapiens Gene: CARD16
Summary
InnateDB Gene IDBG-69692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD16
Gene Name caspase recruitment domain family, member 16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204397
Encoded Proteins
IDBP-69694
caspase recruitment domain family, member 16
IDBP-69696
caspase recruitment domain family, member 16
IDBP-590035
caspase recruitment domain family, member 16
IDBP-589462
caspase recruitment domain family, member 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11536016
CARD16 is an intracellular regulator of CASP1 activation and plays a role in the regulation of IL1B secretion and NF-kappaB activation during the pro-inflammatory cytokine response.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:105041326-105101431
Strand Reverse strand
Band q22.3
Transcripts
ENST00000375706 ENSP00000364858
ENST00000375704 ENSP00000364856
ENST00000525374 ENSP00000433700
ENST00000528513 ENSP00000432485
ENST00000527065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q5EG05
TrEMBL
UniProt Splice Variant
Entrez Gene 114769
UniGene Hs.348365
RefSeq NM_052889 NM_001017534
HUGO HGNC:33701
OMIM 615680
CCDS CCDS41705 CCDS31661
HPRD 16740
IMGT
EMBL AF367017 AK311902 AY885669 BC117478 BC117480 CH471065
GenPept AAI17479 AAI17481 AAK71682 AAW78563 BAG34843 EAW67062
RNA Seq Atlas 114769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca