Version 5.4
Homo sapiens Protein: CARD16
Summary
InnateDB Protein IDBP-69694.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD16
Protein Name caspase recruitment domain family, member 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364858
InnateDB Gene IDBG-69692 (CARD16)
Protein Structure
UniProt Annotation
Function Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269PubMed:11432859, ECO:0000269PubMed:11536016, ECO:0000269PubMed:16920334}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269PubMed:11432859, ECO:0000269PubMed:11536016}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EG05
PhosphoSite PhosphoSite-
TrEMBL E9PQW1
UniProt Splice Variant
Entrez Gene 114769
UniGene Hs.348365
RefSeq NP_001017534
HUGO HGNC:33701
OMIM 615680
CCDS CCDS31661
HPRD 16740
IMGT
EMBL AF367017 AK311902 AP001153 AY885669 BC117478 BC117480 CH471065
GenPept AAI17479 AAI17481 AAK71682 AAW78563 BAG34843 EAW67062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca