Version 5.4
| Homo sapiens Gene: NLRP7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-69828.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | NLRP7 | ||||||||||||||||||
| Gene Name | NLR family, pyrin domain containing 7 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000167634 | ||||||||||||||||||
| Encoded Proteins |
NLR family, pyrin domain containing 7
NLR family, pyrin domain containing 7
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
NLRP7 is a member of the PYRIN-containing apoptotic protease-activating factor-1-like proteins that functions as a feedback regulator of CASP1-dependent interleukin-1beta secretion.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:54923509-54966312 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.42 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q8WX94 | ||||||||||||||||||
| TrEMBL | K7EP54 K7EPY3 K7ER92 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 199713 | ||||||||||||||||||
| UniGene | Hs.351118 | ||||||||||||||||||
| RefSeq | XM_006725766 XM_006725955 XM_006726054 XM_006726152 XM_006726192 XM_006726272 NM_001127255 NM_139176 NM_206828 XM_006723077 XM_006725867 | ||||||||||||||||||
| HUGO | HGNC:22947 | ||||||||||||||||||
| OMIM | 609661 | ||||||||||||||||||
| CCDS | CCDS33109 CCDS12912 CCDS46183 | ||||||||||||||||||
| HPRD | 10112 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC011476 AF464765 AY154462 BC109125 BK001113 | ||||||||||||||||||
| GenPept | AAI09126 AAL69963 AAO18158 DAA01246 | ||||||||||||||||||
| RNA Seq Atlas | 199713 | ||||||||||||||||||