Version 5.4
Homo sapiens Gene: ARHGEF4
Summary
InnateDB Gene IDBG-69993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF4
Gene Name Rho guanine nucleotide exchange factor (GEF) 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136002
Encoded Proteins
IDBP-69995
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-69997
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-244608
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-294247
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-294240
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-385992
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-385993
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-604125
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-604133
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-806538
Rho guanine nucleotide exchange factor (GEF) 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130836916-131047263
Strand Forward strand
Band q21.1
Transcripts
ENST00000326016 ENSP00000316845
ENST00000355771 ENSP00000348017
ENST00000392953 ENSP00000376680
ENST00000409359 ENSP00000386794
ENST00000409303 ENSP00000387285
ENST00000439368
ENST00000428230 ENSP00000398455
ENST00000438985 ENSP00000389661
ENST00000496764
ENST00000490728
ENST00000526381
ENST00000525839 ENSP00000432267
ENST00000528247
ENST00000532720 ENSP00000432301
ENST00000527365
ENST00000525092
ENST00000611048 ENSP00000483548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0030032 lamellipodium assembly
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0032587 ruffle membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.469935 Hs.712345
RefSeq NM_015320 NM_032995 XM_005263685 XM_005263686 XM_005263687 XM_005275931 XM_005275932
HUGO
OMIM
CCDS CCDS2165 CCDS42754
HPRD 05559
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca