InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF4

Summary

InnateDB Protein

IDBP-69997.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF4

Protein Name

Rho guanine nucleotide exchange factor (GEF) 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348017

InnateDB Gene

IDBG-69993 (ARHGEF4)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269PubMed:10947987, ECO:0000269PubMed:12598901, ECO:0000269PubMed:17145773, ECO:0000269PubMed:17599059, ECO:0000269PubMed:19893577}.

Subcellular Localization

Isoform 3: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269PubMed:10873612, ECO:0000269PubMed:17145773, ECO:0000269PubMed:19893577}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0030032	lamellipodium assembly
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway