Version 5.4
Homo sapiens Gene: SUV420H2
Summary
InnateDB Gene IDBG-70538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUV420H2
Gene Name suppressor of variegation 4-20 homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133247
Encoded Proteins
IDBP-70540
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-385393
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-766165
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55339853-55348120
Strand Forward strand
Band q13.42
Transcripts
ENST00000255613 ENSP00000255613
ENST00000402499
ENST00000445196 ENSP00000397296
ENST00000498738
ENST00000464185
ENST00000468951
ENST00000460956
ENST00000474492
ENST00000587442
ENST00000589338
ENST00000592631 ENSP00000467499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042799 histone methyltransferase activity (H4-K20 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0034770 histone H4-K20 methylation
GO:0034773 histone H4-K20 trimethylation
Cellular Component
GO:0000780 condensed nuclear chromosome, centromeric region
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059851
View Gene Order
ENSBTAG00000014087
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.590982
RefSeq NM_032701 XM_005259338 XM_006723442
HUGO
OMIM
CCDS CCDS12922
HPRD 15454
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca