InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUV420H2

Summary

InnateDB Protein

IDBP-70540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUV420H2

Protein Name

suppressor of variegation 4-20 homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255613

InnateDB Gene

IDBG-70538 (SUV420H2)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042799	histone methyltransferase activity (H4-K20 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016571	histone methylation
GO:0034770	histone H4-K20 methylation
GO:0034773	histone H4-K20 trimethylation