InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL18

Summary

InnateDB Gene

IDBG-71390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL18

Gene Name

interleukin 18 (interferon-gamma-inducing factor)

Synonyms

IGIF; IL-18; IL-1g; IL1F4

Species

Homo sapiens

Ensembl Gene

ENSG00000150782

Encoded Proteins

IDBP-71392

interleukin 18 (interferon-gamma-inducing factor)

IDBP-600776

interleukin 18 (interferon-gamma-inducing factor)

IDBP-585049

interleukin 18 (interferon-gamma-inducing factor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20195505

IL18 and IL1B are important pro-inflammatory cytokines that activates monocytes, macropages, and neutrophils, as well as induce the Th1 and Th17 adaptive cellular responses.

PMID 22940097

IL18 secreted by inflammatory monocytes is critical for the differentiation of memory CD8(+) T and NK lymphocytes into antimicrobial effector cells. (Demonstrated in mice)

PMID 25732728

Primary γδ T cells provide an early source of IFNG during dengue virus (DV) infection and target DV-infected cells. Monocytes also participate as accessory cells that sense DV infection and amplify the cellular immune response in an IL18-dependent manner.

InnateDB Annotation from Orthologs

Summary

PMID 22940097

[Mus musculus] Il18 secreted by inflammatory monocytes is critical for the differentiation of CD8(+) T and NK lymphocytes into antimicrobial effector cells.

PMID 24549849

[Mus musculus] Both Nlrp3 and Nlrp1a are important regulators of Toxoplasma proliferation and Il18 signaling is required to mediate host resistance to acute toxoplasmosis.

PMID 25395539

[Mus musculus] Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.

PMID 25689249

[Mus musculus] Activation of the Nlrp3 inflammasome is detrimental during leishmaniasis. Mice lacking the inflammasome components Nlrp3, Pycard, Casp1 exhibit defective Il1b and Il18 production at the infection site and are resistant to cutaneous Leishmania major infection.

PMID 25680273

[Mus musculus] Il22 augments the expression of Il18 mRNA and inactive precursor protein (proIL-18) in intestinal epithelial cells after Toxoplasma gondii or Citrobacter rodentium infection and maintains the homeostatic amount of proIL-18 in the ileum.

PMID 26638072

[Mus musculus] Microbiota-associated metabolites modulate Nlrp6 inflammasome signalling, epithelial Il18 secretion, and anti-microbial pathways.

PMID 26638073

[Mus musculus] Colitis severity is controlled at the level of Il18 signalling in intestinal epithelial cells.

Entrez Gene

Summary

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:112143251-112164117

Strand

Reverse strand

Band

q23.1

Transcripts

ENST00000280357	ENSP00000280357
ENST00000524595	ENSP00000434561
ENST00000525547
ENST00000528832	ENSP00000434161
ENST00000533858
ENST00000534225

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0010628	positive regulation of gene expression
GO:0030101	natural killer cell activation
GO:0030155	regulation of cell adhesion
GO:0030431	sleep
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0034105	positive regulation of tissue remodeling
GO:0042033	chemokine biosynthetic process
GO:0042088	T-helper 1 type immune response
GO:0042092	type 2 immune response
GO:0042094	interleukin-2 biosynthetic process
GO:0042095	interferon-gamma biosynthetic process
GO:0042104	positive regulation of activated T cell proliferation
GO:0042231	interleukin-13 biosynthetic process
GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0051142	positive regulation of NK T cell proliferation
GO:0071407	cellular response to organic cyclic compound