Version 5.4
Homo sapiens Gene: BCO2
Summary
InnateDB Gene IDBG-71455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCO2
Gene Name beta-carotene oxygenase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197580
Encoded Proteins
IDBP-71457
beta-carotene oxygenase 2
IDBP-71461
beta-carotene oxygenase 2
IDBP-383123
beta-carotene oxygenase 2
IDBP-594037
beta-carotene oxygenase 2
IDBP-584812
beta-carotene oxygenase 2
IDBP-601680
beta-carotene oxygenase 2
IDBP-584007
beta-carotene oxygenase 2
IDBP-591754
beta-carotene oxygenase 2
IDBP-593414
beta-carotene oxygenase 2
IDBP-590520
beta-carotene oxygenase 2
IDBP-595346
beta-carotene oxygenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:112175467-112224699
Strand Forward strand
Band q23.1
Transcripts
ENST00000357685 ENSP00000350314
ENST00000361053 ENSP00000354338
ENST00000438022 ENSP00000414843
ENST00000461480
ENST00000460924
ENST00000494860
ENST00000534550 ENSP00000434488
ENST00000531003 ENSP00000435869
ENST00000527939 ENSP00000436956
ENST00000534122
ENST00000526088 ENSP00000436615
ENST00000532593 ENSP00000431802
ENST00000531169 ENSP00000437053
ENST00000530677 ENSP00000432045
ENST00000527198
ENST00000525175 ENSP00000431882
ENST00000532716
ENST00000532673
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0016116 carotenoid metabolic process
GO:0016119 carotene metabolic process
GO:0016121 carotene catabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0051881 regulation of mitochondrial membrane potential
GO:0055114 oxidation-reduction process
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032066
View Gene Order
ENSBTAG00000034193
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.728325
RefSeq NM_001037290 NM_001256397 NM_001256398 NM_001256400 NM_031938
HUGO
OMIM
CCDS CCDS41716 CCDS58181 CCDS58182 CCDS58183 CCDS8358
HPRD 12522
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca