Version 5.4
Homo sapiens Gene: PEG3
Summary
InnateDB Gene IDBG-71716.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEG3
Gene Name paternally expressed 3
Synonyms PW1; ZKSCAN22; ZNF904; ZSCAN24
Species Homo sapiens
Ensembl Gene ENSG00000198300
Encoded Proteins
IDBP-71722
zinc finger, imprinted 2
IDBP-765516
IDBP-764691
IDBP-765128
IDBP-764981
IDBP-766090
IDBP-759798
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5\' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5\' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:56810083-56840728
Strand Reverse strand
Band q13.43
Transcripts
ENST00000326441 ENSP00000326581
ENST00000594389 ENSP00000469144
ENST00000596261
ENST00000600833 ENSP00000470467
ENST00000599565
ENST00000598410 ENSP00000473190
ENST00000599577 ENSP00000469486
ENST00000593695 ENSP00000472402
ENST00000594706
ENST00000599534 ENSP00000472395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0010468 regulation of gene expression
GO:0035264 multicellular organism growth
GO:0071514 genetic imprinting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002265
View Gene Order
ENSBTAG00000023338
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731875
RefSeq NM_001146184 NM_001146185 NM_001146186 NM_001146187 NM_006210
HUGO
OMIM
CCDS CCDS12948 CCDS58684 CCDS58685
HPRD 03285
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca