Mus musculus Gene: Peg3
Summary
InnateDB Gene IDBG-141100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Peg3
Gene Name paternally expressed 3
Synonyms AL022617; ASF-1; End4; Gcap4; mKIAA0287; Pw1; Zfp102;
Species Mus musculus
Ensembl Gene ENSMUSG00000002265
Encoded Proteins
paternally expressed 3
paternally expressed 3
paternally expressed 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198300:
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5\' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5\' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:6703892-6730421
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000051209 ENSMUSP00000050750
ENSMUST00000150182 ENSMUSP00000116161
ENSMUST00000143703 ENSMUSP00000122423
ENSMUST00000155910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0010468 regulation of gene expression
GO:0035264 multicellular organism growth
GO:0071514 genetic imprinting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q3URU2
TrEMBL D6RGA4 Q0P5Y8
UniProt Splice Variant
Entrez Gene 18616
UniGene Mm.389800 Mm.471005 Mm.473952
RefSeq NM_008817
OMIM
CCDS CCDS20783
HPRD
IMGT
MGI ID MGI:104748
MGI Symbol Peg3
EMBL AB003040 AC157657 AF038939 AF105264 AF105265 AF105266 AK122238 AK141217 AK163845 BC048778 BC072661 BC085183 BC089344 U48804
GenPept AAB96922 AAC52770 AAF16868 AAH48778 AAH72661 AAH85183 AAH89344 BAB85589 BAC65520 BAE24595 BAE37516
RNA Seq Atlas 18616