Version 5.4
Homo sapiens Gene: AURKC
Summary
InnateDB Gene IDBG-71872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AURKC
Gene Name aurora kinase C
Synonyms AIE2; AIK3; ARK3; AurC; aurora-C; SPGF5; STK13
Species Homo sapiens
Ensembl Gene ENSG00000105146
Encoded Proteins
IDBP-71874
aurora kinase C
IDBP-385547
aurora kinase C
IDBP-385549
aurora kinase C
IDBP-765612
IDBP-761478
IDBP-763843
IDBP-766012
IDBP-763239
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:57230802-57235548
Strand Forward strand
Band q13.43
Transcripts
ENST00000302804 ENSP00000302898
ENST00000415300 ENSP00000407162
ENST00000448930 ENSP00000406798
ENST00000598785 ENSP00000471830
ENST00000601799 ENSP00000468918
ENST00000594599 ENSP00000469894
ENST00000596375 ENSP00000470465
ENST00000599062 ENSP00000469983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0007126 meiotic nuclear division
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0016570 histone modification
GO:0032467 positive regulation of cytokinesis
GO:0051256 spindle midzone assembly involved in mitosis
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:0051233 spindle midzone
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
aurora_c_pathway
Aurora C signaling
aurora_b_pathway
Aurora B signaling
aurora_kinase_pathway
Signaling by Aurora kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.98338
RefSeq NM_001015878 NM_001015879 NM_003160
HUGO
OMIM
CCDS CCDS33128 CCDS46205 CCDS46206
HPRD 04605
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca