InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AURKC

Summary

InnateDB Protein

IDBP-765612.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AURKC

Protein Name

Synonyms

AIE2; AIK3; ARK3; AurC; aurora-C; SPGF5; STK13;

Species

Homo sapiens

Ensembl Protein

ENSP00000471830

InnateDB Gene

IDBG-71872 (AURKC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000910	cytokinesis
GO:0006468	protein phosphorylation
GO:0007126	meiotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0016570	histone modification
GO:0032467	positive regulation of cytokinesis
GO:0051256	spindle midzone assembly involved in mitosis

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0051233	spindle midzone

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt