Homo sapiens Gene: FSCN2
Summary
InnateDB Gene IDBG-72335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSCN2
Gene Name fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Synonyms RFSN; RP30;
Species Homo sapiens
Ensembl Gene ENSG00000186765
Encoded Proteins
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81528396-81537130
Strand Forward strand
Band q25.3
Transcripts
ENST00000334850 ENSP00000334665
ENST00000417245 ENSP00000388716
ENST00000527221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0030674 protein binding, bridging
GO:0051015 actin filament binding
Biological Process
GO:0007601 visual perception
GO:0009653 anatomical structure morphogenesis
GO:0030036 actin cytoskeleton organization
GO:0042462 eye photoreceptor cell development
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0032420 stereocilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O14926
TrEMBL
UniProt Splice Variant
Entrez Gene 25794
UniGene Hs.118555
RefSeq NM_012418 XM_005257196 NM_001077182 XM_005257195
HUGO HGNC:3960
OMIM 607643
CCDS CCDS45811 CCDS45810
HPRD 06366
IMGT
EMBL AC137896 AC139149 AF030165 AF066062 AF066063 AF066064 AF066065 BC126295 BC130330
GenPept AAB86481 AAC18604 AAI26296 AAI30331
RNA Seq Atlas 25794