Homo sapiens Gene: PDE6G
Summary
InnateDB Gene IDBG-72421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE6G
Gene Name phosphodiesterase 6G, cGMP-specific, rod, gamma
Synonyms PDEG; RP57;
Species Homo sapiens
Ensembl Gene ENSG00000185527
Encoded Proteins
phosphodiesterase 6G, cGMP-specific, rod, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81650459-81663112
Strand Reverse strand
Band q25.3
Transcripts
ENST00000331056 ENSP00000328412
ENST00000573076 ENSP00000458567
ENST00000574024 ENSP00000460962
ENST00000571224 ENSP00000458167
ENST00000571004 ENSP00000461464
ENST00000574777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0030507 spectrin binding
GO:0030553 cGMP binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0008152 metabolic process
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0043086 negative regulation of catalytic activity
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0097381 photoreceptor disc membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ca2+ pathway pathway
Activation of the phototransduction cascade pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
The phototransduction cascade pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Disease pathway
KEGG
Purine metabolism pathway
Phototransduction pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
Visual signal transduction [Biocarta view]
PID NCI
Visual signal transduction: Rods
Cross-References
SwissProt P18545
TrEMBL
UniProt Splice Variant
Entrez Gene 5148
UniGene Hs.654482
RefSeq NM_002602 XM_006721942
HUGO HGNC:8789
OMIM 180073
CCDS CCDS11783
HPRD 08914
IMGT
EMBL BC106884 BX537414 CH471099 M36476 U00481 U00482 X62025
GenPept AAA03653 AAA60044 AAI06885 CAA43975 CAD97656 EAW89666
RNA Seq Atlas 5148