InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE6G

Summary

InnateDB Gene

IDBG-72421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE6G

Gene Name

phosphodiesterase 6G, cGMP-specific, rod, gamma

Synonyms

PDEG; RP57

Species

Homo sapiens

Ensembl Gene

ENSG00000185527

Encoded Proteins

IDBP-72423

phosphodiesterase 6G, cGMP-specific, rod, gamma

IDBP-764627

IDBP-758765

IDBP-761840

IDBP-759732

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81650459-81663112

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000331056	ENSP00000328412
ENST00000573076	ENSP00000458567
ENST00000574024	ENSP00000460962
ENST00000571224	ENSP00000458167
ENST00000571004	ENSP00000461464
ENST00000574777

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0030553	cGMP binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0008152	metabolic process
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0043086	negative regulation of catalytic activity
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway