Version 5.4
Homo sapiens Gene: SLC16A8
Summary
InnateDB Gene IDBG-7273.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A8
Gene Name solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
Synonyms MCT3; REMP
Species Homo sapiens
Ensembl Gene ENSG00000100156
Encoded Proteins
IDBP-7275
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
IDBP-376263
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38078134-38084093
Strand Reverse strand
Band q13.1
Transcripts
ENST00000320521 ENSP00000321735
ENST00000427592 ENSP00000409547
ENST00000469516
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015129 lactate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
Biological Process
GO:0006090 pyruvate metabolic process
GO:0007596 blood coagulation
GO:0015711 organic anion transport
GO:0015727 lactate transport
GO:0035873 lactate transmembrane transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032988
View Gene Order
ENSBTAG00000015275
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_20515
Proton-coupled monocarboxylate transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_2071
Pyruvate metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B0QYL4
UniProt Splice Variant
Entrez Gene 23539
UniGene Hs.743654
RefSeq NM_013356
HUGO HGNC:16270
OMIM 610409
CCDS CCDS13966
HPRD 11568
IMGT
EMBL AL031587
GenPept
RNA Seq Atlas 23539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca