Homo sapiens Gene: SLC16A8
Summary
InnateDB Gene IDBG-7273.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A8
Gene Name solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
Synonyms MCT3; REMP;
Species Homo sapiens
Ensembl Gene ENSG00000100156
Encoded Proteins
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38078134-38084093
Strand Reverse strand
Band q13.1
Transcripts
ENST00000320521 ENSP00000321735
ENST00000427592 ENSP00000409547
ENST00000469516
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015129 lactate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
Biological Process
GO:0006090 pyruvate metabolic process
GO:0007596 blood coagulation
GO:0015711 organic anion transport
GO:0015727 lactate transport
GO:0035873 lactate transmembrane transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
Basigin interactions pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
Proton-coupled monocarboxylate transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743654
RefSeq NM_013356
HUGO
OMIM
CCDS CCDS13966
HPRD 11568
IMGT
EMBL
GenPept
RNA Seq Atlas