InnateDB Protein
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IDBP-7275.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC16A8
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Protein Name
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solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
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Synonyms
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MCT3; REMP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000321735
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InnateDB Gene
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IDBG-7273 (SLC16A8)
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Protein Structure
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Function |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Retinal pigment epithelium.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015129
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lactate transmembrane transporter activity
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GO:0015293
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symporter activity
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GO:0015355
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secondary active monocarboxylate transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004743
Monocarboxylate transporter
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95907
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PhosphoSite |
PhosphoSite-O95907
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TrEMBL |
B0QYL4
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UniProt Splice Variant |
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Entrez Gene |
23539
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UniGene |
Hs.743654
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RefSeq |
NP_037488
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HUGO |
HGNC:16270
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OMIM |
610409
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CCDS |
CCDS13966
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HPRD |
11568
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IMGT |
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EMBL |
AF132610
AF132611
AL031587
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GenPept |
AAF03489
AAF03565
CAB37479
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