InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ANAPC11

Summary

InnateDB Gene

IDBG-72756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANAPC11

Gene Name

anaphase promoting complex subunit 11

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000141552

Encoded Proteins

IDBP-72758

anaphase promoting complex subunit 11

IDBP-72760

anaphase promoting complex subunit 11

IDBP-245788

anaphase promoting complex subunit 11

IDBP-764938

IDBP-764272

IDBP-761341

IDBP-762355

IDBP-763328

IDBP-759460

IDBP-762645

IDBP-760477

IDBP-761723

IDBP-763528

IDBP-762246

IDBP-759723

IDBP-764189

IDBP-757890

IDBP-761096

IDBP-757809

IDBP-763684

IDBP-760076

IDBP-812515

anaphase promoting complex subunit 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81890790-81900991

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000357385	ENSP00000349957
ENST00000344877	ENSP00000339695
ENST00000392376	ENSP00000376181
ENST00000571570	ENSP00000458143
ENST00000575195	ENSP00000458515
ENST00000577747	ENSP00000463567
ENST00000572639	ENSP00000460678
ENST00000583839	ENSP00000463598
ENST00000574924	ENSP00000460064
ENST00000584314	ENSP00000462250
ENST00000571874	ENSP00000459200
ENST00000572851	ENSP00000458265
ENST00000579978	ENSP00000463640
ENST00000578544	ENSP00000463357
ENST00000571024	ENSP00000461648
ENST00000585259	ENSP00000462527
ENST00000573956
ENST00000578550	ENSP00000464615
ENST00000582222	ENSP00000464403
ENST00000584197	ENSP00000464519
ENST00000577425	ENSP00000462691
ENST00000579133	ENSP00000463889
ENST00000612413	ENSP00000484031

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979	protein K11-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005730	nucleolus
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025135

View Gene Order

ENSBTAG00000001937

Not yet available

Pathways

NETPATH

REACTOME

REACT_1072

Inactivation of APC/C via direct inhibition of the APC/C complex pathway

REACT_1041

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway

REACT_6761

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway

REACT_6820

APC/C:Cdc20 mediated degradation of Cyclin B pathway

REACT_6871

APC/C:Cdc20 mediated degradation of Securin pathway

REACT_6781

APC/C:Cdc20 mediated degradation of mitotic proteins pathway

REACT_6904

Phosphorylation of the APC/C pathway

REACT_6785

Autodegradation of Cdh1 by Cdh1:APC/C pathway

REACT_6867

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway

REACT_6837

Regulation of APC/C activators between G1/S and early anaphase pathway

REACT_150471

Separation of Sister Chromatids pathway

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_120956

Cellular responses to stress pathway

REACT_6828

APC/C-mediated degradation of cell cycle proteins pathway

REACT_6954

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway

REACT_21279

Regulation of mitotic cell cycle pathway

REACT_115566

Cell Cycle pathway

REACT_75774

Adaptive Immune System pathway

REACT_2137

Mitotic Spindle Checkpoint pathway

REACT_6900

Immune System pathway

REACT_910

M Phase pathway

REACT_169274

Cellular Senescence pathway

REACT_1275

Mitotic Anaphase pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_169168

Senescence-Associated Secretory Phenotype (SASP) pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

REACT_1538

Cell Cycle Checkpoints pathway

REACT_150314

Mitotic Metaphase and Anaphase pathway

KEGG

hsa04110

Cell cycle pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa04114

Oocyte meiosis pathway

INOH

PID NCI

Cross-References

SwissProt

Q9NYG5

TrEMBL

UniProt Splice Variant

Entrez Gene

51529

UniGene

RefSeq

NM_001289414 NM_001002244 NM_001002245 NM_001002246 NM_001002247 NM_001002248 NM_001002249 NM_001289415 NM_001289416 NM_001289417 NM_001289418 NM_001289419 NM_016476

HUGO

HGNC:14452

OMIM

614534

CCDS

CCDS11789 CCDS32769 CCDS74180

HPRD

12452

IMGT

EMBL

AC145207 AF151048 AF247565 AF247789 BC000607 BC066308 BC095454 BC104641 BC171892 BC171898 BC171899 BC171900

GenPept

AAF36134 AAF65816 AAH00607 AAH66308 AAH95454 AAI04642 AAI71892 AAI71898 AAI71899 AAI71900 AAL95694

RNA Seq Atlas

51529