Version 5.4
Homo sapiens Gene: PCYT2
Summary
InnateDB Gene IDBG-72805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCYT2
Gene Name phosphate cytidylyltransferase 2, ethanolamine
Synonyms ET
Species Homo sapiens
Ensembl Gene ENSG00000185813
Encoded Proteins
IDBP-72807
phosphate cytidylyltransferase 2, ethanolamine
IDBP-595411
phosphate cytidylyltransferase 2, ethanolamine
IDBP-600676
phosphate cytidylyltransferase 2, ethanolamine
IDBP-764566
IDBP-762562
IDBP-762855
IDBP-759257
IDBP-758810
IDBP-762944
IDBP-764924
IDBP-764260
IDBP-761927
IDBP-761179
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81900965-81911464
Strand Reverse strand
Band q25.3
Transcripts
ENST00000331285 ENSP00000331719
ENST00000538721 ENSP00000442050
ENST00000538936 ENSP00000439245
ENST00000573636 ENSP00000459836
ENST00000571105 ENSP00000459044
ENST00000573401 ENSP00000458472
ENST00000571944
ENST00000573927 ENSP00000458727
ENST00000570391 ENSP00000461190
ENST00000571581
ENST00000574343
ENST00000570388 ENSP00000458330
ENST00000574155
ENST00000572473 ENSP00000458805
ENST00000572157 ENSP00000461814
ENST00000572995 ENSP00000460767
ENST00000576343 ENSP00000458931
ENST00000572924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0009058 biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025137
View Gene Order
ENSBTAG00000001868
Not yet available
Pathways
NETPATH
REACTOME
REACT_120919
Synthesis of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001184917 NM_001256433 NM_001256434 NM_001256435 NM_001282203 NM_001282204 NM_002861
HUGO
OMIM
CCDS CCDS11791 CCDS54178 CCDS58610 CCDS62364
HPRD 04059
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca