Homo sapiens Gene: PCYT2
Summary
InnateDB Gene IDBG-72805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCYT2
Gene Name phosphate cytidylyltransferase 2, ethanolamine
Synonyms ET;
Species Homo sapiens
Ensembl Gene ENSG00000185813
Encoded Proteins
phosphate cytidylyltransferase 2, ethanolamine
phosphate cytidylyltransferase 2, ethanolamine
phosphate cytidylyltransferase 2, ethanolamine
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81900965-81911464
Strand Reverse strand
Band q25.3
Transcripts
ENST00000331285 ENSP00000331719
ENST00000538721 ENSP00000442050
ENST00000538936 ENSP00000439245
ENST00000573636 ENSP00000459836
ENST00000571105 ENSP00000459044
ENST00000573401 ENSP00000458472
ENST00000571944
ENST00000573927 ENSP00000458727
ENST00000570391 ENSP00000461190
ENST00000571581
ENST00000574343
ENST00000570388 ENSP00000458330
ENST00000574155
ENST00000572473 ENSP00000458805
ENST00000572157 ENSP00000461814
ENST00000572995 ENSP00000460767
ENST00000576343 ENSP00000458931
ENST00000572924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0009058 biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Synthesis of PE pathway
Metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99447
TrEMBL I3L1C4 I3L1F9
UniProt Splice Variant
Entrez Gene 5833
UniGene
RefSeq NM_001282204 NM_001282203 NM_002861 NM_001256434 NM_001184917 NM_001256435 NM_001256433
HUGO HGNC:8756
OMIM 602679
CCDS CCDS62364 CCDS58610 CCDS11791 CCDS54178
HPRD 04059
IMGT
EMBL AC145207 AK301723 AK316385 BC000351 BC010075 CH471099 CR456779 D84307
GenPept AAH00351 AAH10075 BAA12311 BAH13541 BAH14756 CAG33060 EAW89705
RNA Seq Atlas 5833