Homo sapiens Gene: FBXO17
Summary
InnateDB Gene IDBG-728125.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO17
Gene Name F-box protein 17
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000269190
Encoded Proteins
F-box protein 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing of this gene results in 2 transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38941401-38975910
Strand Reverse strand
Band q13.2
Transcripts
ENST00000292852 ENSP00000292852
ENST00000601394 ENSP00000469852
ENST00000597696
ENST00000595329 ENSP00000470361
ENST00000596025 ENSP00000470101
ENST00000599418
ENST00000599598 ENSP00000470390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0QYI3
UniProt Splice Variant
Entrez Gene 115290
UniGene
RefSeq NM_024907 NM_148169
HUGO HGNC:18754
OMIM 609094
CCDS CCDS12526
HPRD 16436
IMGT
EMBL AC011455
GenPept
RNA Seq Atlas 115290