Version 5.4
Homo sapiens Gene: TGIF2
Summary
InnateDB Gene IDBG-72851.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGIF2
Gene Name TGFB-induced factor homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118707
Encoded Proteins
IDBP-72853
TGFB-induced factor homeobox 2
IDBP-72855
TGFB-induced factor homeobox 2
IDBP-594418
TGFB-induced factor homeobox 2
IDBP-591413
TGFB-induced factor homeobox 2
IDBP-813380
TGFB-induced factor homeobox 2
IDBP-813381
TGFB-induced factor homeobox 2
IDBP-813382
TGFB-induced factor homeobox 2
IDBP-813383
TGFB-induced factor homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:36573488-36593950
Strand Forward strand
Band q11.23
Transcripts
ENST00000373874 ENSP00000362981
ENST00000373872 ENSP00000362979
ENST00000558028 ENSP00000452878
ENST00000560025 ENSP00000453773
ENST00000561398 ENSP00000475729
ENST00000557885 ENSP00000476174
ENST00000558465 ENSP00000475479
ENST00000611732 ENSP00000481787
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0010470 regulation of gastrulation
GO:0038092 nodal signaling pathway
GO:0045666 positive regulation of neuron differentiation
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 60436
UniGene
RefSeq NM_001199513 NM_001199514 NM_001199515 NM_021809
HUGO HGNC:15764
OMIM 607294
CCDS CCDS13278
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 60436

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca