InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGIF2

Summary

InnateDB Protein

IDBP-72855.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGIF2

Protein Name

TGFB-induced factor homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362979

InnateDB Gene

IDBG-72851 (TGIF2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269PubMed:11427533}.

Subcellular Localization

Nucleus. Note=Excluded from nucleoli.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression