Version 5.4
Homo sapiens Gene: CYTIP
Summary
InnateDB Gene IDBG-72874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYTIP
Gene Name cytohesin 1 interacting protein
Synonyms B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP
Species Homo sapiens
Ensembl Gene ENSG00000115165
Encoded Proteins
IDBP-72876
cytohesin 1 interacting protein
IDBP-386746
cytohesin 1 interacting protein
IDBP-386748
cytohesin 1 interacting protein
IDBP-386749
cytohesin 1 interacting protein
IDBP-386750
cytohesin 1 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17577583
CYTIP co-localizes with SNX27 at the early endosomal compartment of lymphocytes suggesting a role for this interaction in endocytic trafficking and/or signalling.
Entrez Gene
Summary The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:157414619-157488961
Strand Reverse strand
Band q24.1
Transcripts
ENST00000264192 ENSP00000264192
ENST00000418920 ENSP00000394308
ENST00000457793 ENSP00000407205
ENST00000439355 ENSP00000402771
ENST00000435117 ENSP00000402155
ENST00000497432
ENST00000462109
ENST00000483929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030155 regulation of cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005938 cell cortex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026832
View Gene Order
ENSBTAG00000008329
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.270 Hs.737437
RefSeq NM_004288
HUGO
OMIM
CCDS CCDS2204
HPRD 09192
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca