InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYTIP

Summary

InnateDB Protein

IDBP-72876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYTIP

Protein Name

cytohesin 1 interacting protein

Synonyms

B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000264192

InnateDB Gene

IDBG-72874 (CYTIP)

Protein Structure

UniProt Annotation

Function

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

Subcellular Localization

Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27.

Disease Associations

Tissue Specificity

Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow. {ECO:0000269PubMed:11867758, ECO:0000269PubMed:12606567}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0030155	regulation of cell adhesion
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005938	cell cortex

Protein Structure and Domains

PDB ID

InterPro

IPR001478 PDZ domain

PFAM

PF00595
PF13180

PRINTS

PIRSF

SMART

SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60759

PhosphoSite

PhosphoSite-O60759

TrEMBL

C9JSM2

UniProt Splice Variant

Entrez Gene

9595

UniGene

Hs.737437

RefSeq

NP_004279

HUGO

HGNC:9506

OMIM

604448

CCDS

CCDS2204

HPRD

09192

IMGT

EMBL

AC019201 AF068836 AK301544 BC036449 L06633

GenPept

AAA16575 AAC19129 AAH36449 AAY14898 BAG63041