Homo sapiens Gene: PIK3R2
InnateDB Gene IDBG-729145.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3R2
Gene Name PIK3R2 protein
Synonyms MPPH; MPPH1; p85; p85-BETA; P85B;
Species Homo sapiens
Ensembl Gene ENSG00000268173
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18153158-18178117
Strand Forward strand
Band p13.11
ENST00000593731 ENSP00000471914
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030971 receptor tyrosine kinase binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
No orthologs found for this gene
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Carbohydrate digestion and absorption pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Amoebiasis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
UniProt Splice Variant
Entrez Gene 5296
UniGene Hs.708970
OMIM 603157
EMBL AC007192 BC014170 BC070082 BC090249 X80907
GenPept AAD22671 AAH14170 AAH70082 AAH90249 CAA56868
RNA Seq Atlas 5296