Version 5.4
Homo sapiens Gene: PIK3R2
Summary
InnateDB Gene IDBG-729145.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3R2
Gene Name PIK3R2 protein
Synonyms MPPH; MPPH1; p85; p85-BETA; P85B
Species Homo sapiens
Ensembl Gene ENSG00000268173
Encoded Proteins
IDBP-762537
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18153158-18178117
Strand Forward strand
Band p13.11
Transcripts
ENST00000593731 ENSP00000471914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030971 receptor tyrosine kinase binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04210
Apoptosis pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
hsa04973
Carbohydrate digestion and absorption pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q96CK7
UniProt Splice Variant
Entrez Gene 5296
UniGene Hs.708970
RefSeq
HUGO HGNC:8980
OMIM 603157
CCDS CCDS12371
HPRD
IMGT
EMBL AC007192 BC014170 BC070082 BC090249 X80907
GenPept AAD22671 AAH14170 AAH70082 AAH90249 CAA56868
RNA Seq Atlas 5296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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