Version 5.4
Homo sapiens Gene: SPIB
Summary
InnateDB Gene IDBG-729211.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPIB
Gene Name Spi-B transcription factor (Spi-1/PU.1 related)
Synonyms SPI-B
Species Homo sapiens
Ensembl Gene ENSG00000269404
Encoded Proteins
IDBP-64475
Spi-B transcription factor (Spi-1/PU.1 related)
IDBP-765987
IDBP-762648
IDBP-763218
IDBP-759948
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5\'-GAGGAA-3\') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50418938-50431313
Strand Forward strand
Band q13.33
Transcripts
ENST00000270632 ENSP00000270632
ENST00000595883 ENSP00000471921
ENST00000596074 ENSP00000470970
ENST00000594685 ENSP00000472626
ENST00000597855 ENSP00000469023
ENST00000599923
ENST00000594188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437905
RefSeq NM_001243998 NM_001243999 NM_001244000 NM_003121
HUGO
OMIM
CCDS CCDS33080 CCDS58674 CCDS59412
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca