InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPIB

Summary

InnateDB Protein

IDBP-64475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPIB

Protein Name

Spi-B transcription factor (Spi-1/PU.1 related)

Synonyms

SPI-B;

Species

Homo sapiens

Ensembl Protein

ENSP00000270632

InnateDB Gene

IDBG-729211 (SPIB)

Protein Structure

UniProt Annotation

Function

Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269PubMed:10196196, ECO:0000269PubMed:12393575, ECO:0000269PubMed:1406622, ECO:0000269PubMed:15583020}.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. {ECO:0000269PubMed:11841448, ECO:0000269PubMed:12393575}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation