Homo sapiens Gene: SLC16A3
Summary
InnateDB Gene IDBG-73352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A3
Gene Name solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
Synonyms MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4;
Species Homo sapiens
Ensembl Gene ENSG00000141526
Encoded Proteins
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
solute carrier family 16 (monocarboxylate transporter), member 3
solute carrier family 16 (monocarboxylate transporter), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:82228397-82261129
Strand Forward strand
Band q25.3
Transcripts
ENST00000392341 ENSP00000376152
ENST00000392339 ENSP00000376150
ENST00000582743 ENSP00000462405
ENST00000579572
ENST00000582946 ENSP00000464381
ENST00000578684 ENSP00000463912
ENST00000580098 ENSP00000463880
ENST00000581287 ENSP00000463978
ENST00000577650 ENSP00000463063
ENST00000580189 ENSP00000464112
ENST00000583444
ENST00000583025 ENSP00000463005
ENST00000581642
ENST00000584781
ENST00000583237 ENSP00000462854
ENST00000584689 ENSP00000464625
ENST00000578810
ENST00000582715 ENSP00000464326
ENST00000578522 ENSP00000463508
ENST00000578574
ENST00000617373 ENSP00000483212
ENST00000619321 ENSP00000482013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0007596 blood coagulation
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0035879 plasma membrane lactate transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
Basigin interactions pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
Proton-coupled monocarboxylate transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3QQV2
UniProt Splice Variant
Entrez Gene 9123
UniGene Hs.500761 Hs.641748
RefSeq NM_001042422 NM_001042423 NM_001206950 NM_001206951 NM_001206952 NM_004207
HUGO HGNC:10924
OMIM 603877
CCDS CCDS11804
HPRD 04854
IMGT
EMBL AC132872
GenPept
RNA Seq Atlas 102465472 9123