Version 5.4
| Homo sapiens Gene: SLC16A3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-73352.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SLC16A3 | ||||||||||||||||||
| Gene Name | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) | ||||||||||||||||||
| Synonyms | MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000141526 | ||||||||||||||||||
| Encoded Proteins |
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
solute carrier family 16 (monocarboxylate transporter), member 3
solute carrier family 16 (monocarboxylate transporter), member 3
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 17:82228397-82261129 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q25.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Basigin interactions pathway
Cell surface interactions at the vascular wall pathway
Proton-coupled monocarboxylate transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Pyruvate metabolism pathway
Transmembrane transport of small molecules pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Hemostasis pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.500761 Hs.641748 | ||||||||||||||||||
| RefSeq | NM_001042422 NM_001042423 NM_001206950 NM_001206951 NM_001206952 NM_004207 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS11804 | ||||||||||||||||||
| HPRD | 04854 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||