InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MSN

Summary

InnateDB Gene

IDBG-73422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSN

Gene Name

moesin

Synonyms

HEL70

Species

Homo sapiens

Ensembl Gene

ENSG00000147065

Encoded Proteins

IDBP-73424

moesin

IDBP-809572

moesin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:65588377-65741931

Strand

Forward strand

Band

q12

Transcripts

ENST00000360270	ENSP00000353408
ENST00000609672	ENSP00000477441
ENST00000609205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	97 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019901	protein kinase binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0006928	cellular component movement
GO:0007159	leukocyte cell-cell adhesion
GO:0010628	positive regulation of gene expression
GO:0022614	membrane to membrane docking
GO:0050900	leukocyte migration
GO:0061028	establishment of endothelial barrier
GO:2000401	regulation of lymphocyte migration

Cellular Component

GO:0001931	uropod
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0030175	filopodium
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031207

View Gene Order

ENSBTAG00000003418

Not yet available

Pathways

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04670

Leukocyte transendothelial migration pathway

INOH

PID NCI

er_nongenomic_pathway

Plasma membrane estrogen receptor signaling

Cross-References

SwissProt

P26038

TrEMBL

V9GZ54 V9HWC0

UniProt Splice Variant

Entrez Gene

4478

UniGene

Hs.87752

RefSeq

NM_002444 XM_005262269

HUGO

HGNC:7373

OMIM

309845

CCDS

CCDS14382

HPRD

02399

IMGT

EMBL

AL391690 BC017293 CH471132 EU794636 M69066 Z98946

GenPept

AAA36322 AAH17293 ACJ13690 CAB46379 EAX05398

RNA Seq Atlas

4478