InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSN

Summary

InnateDB Protein

IDBP-73424.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSN

Protein Name

moesin

Synonyms

HEL70;

Species

Homo sapiens

Ensembl Protein

ENSP00000353408

InnateDB Gene

IDBG-73422 (MSN)

Protein Structure

UniProt Annotation

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. {ECO:0000269PubMed:21549406}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Apical cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269PubMed:18586956}.

Disease Associations

Tissue Specificity

In all tissues and cultured cells studied.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	97 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019901	protein kinase binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0006928	cellular component movement
GO:0007159	leukocyte cell-cell adhesion
GO:0010628	positive regulation of gene expression
GO:0022614	membrane to membrane docking
GO:0050900	leukocyte migration
GO:0061028	establishment of endothelial barrier
GO:2000401	regulation of lymphocyte migration

Cellular Component

GO:0001931	uropod
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0030175	filopodium
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00769
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References