Homo sapiens Gene: TBR1
Summary
InnateDB Gene IDBG-73601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBR1
Gene Name T-box, brain, 1
Synonyms TBR-1; TES-56;
Species Homo sapiens
Ensembl Gene ENSG00000136535
Encoded Proteins
T-box, brain, 1
T-box, brain, 1
T-box, brain, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:161416094-161425870
Strand Forward strand
Band q24.2
Transcripts
ENST00000389554 ENSP00000374205
ENST00000410035 ENSP00000387023
ENST00000411412 ENSP00000393934
ENST00000463544
ENST00000477804
ENST00000489530
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007411 axon guidance
GO:0007420 brain development
GO:0010092 specification of organ identity
GO:0010468 regulation of gene expression
GO:0010975 regulation of neuron projection development
GO:0030182 neuron differentiation
GO:0030902 hindbrain development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.210862 Hs.592557
RefSeq NM_006593
HUGO
OMIM
CCDS CCDS33310
HPRD 07055
IMGT
EMBL
GenPept
RNA Seq Atlas