Version 5.4
Homo sapiens Protein: TBR1
Summary
InnateDB Protein IDBP-73603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBR1
Protein Name T-box, brain, 1
Synonyms TBR-1; TES-56;
Species Homo sapiens
Ensembl Protein ENSP00000374205
InnateDB Gene IDBG-73601 (TBR1)
Protein Structure
UniProt Annotation
Function Probable transcriptional regulator involved in developmental processes. Required for normal brain development.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.
Disease Associations
Tissue Specificity Brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007411 axon guidance
GO:0007420 brain development
GO:0010092 specification of organ identity
GO:0010468 regulation of gene expression
GO:0010975 regulation of neuron projection development
GO:0030182 neuron differentiation
GO:0030902 hindbrain development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001699 Transcription factor, T-box
IPR008967 p53-like transcription factor, DNA-binding
PFAM PF00907
PRINTS PR00937
PIRSF
SMART SM00425
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16650
PhosphoSite PhosphoSite-Q16650
TrEMBL B0AZS4
UniProt Splice Variant
Entrez Gene 10716
UniGene Hs.592557
RefSeq NP_006584
HUGO HGNC:11590
OMIM 604616
CCDS CCDS33310
HPRD 07055
IMGT
EMBL AC009487 AK297438 AK312567 AK315865 AK316161 BC029289 BC104844 BC113418 U49250
GenPept AAA92010 AAH29289 AAI04845 AAI13419 AAY15017 BAF98756 BAG35462 BAH12582 BAH14532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca