InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DPP4

Summary

InnateDB Gene

IDBG-73658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPP4

Gene Name

dipeptidyl-peptidase 4

Synonyms

ADABP; ADCP2; CD26; DPPIV; TP103

Species

Homo sapiens

Ensembl Gene

ENSG00000197635

Encoded Proteins

IDBP-73660

dipeptidyl-peptidase 4

IDBP-387011

dipeptidyl-peptidase 4

IDBP-387012

dipeptidyl-peptidase 4

IDBP-387013

dipeptidyl-peptidase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:161992241-162074542

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000360534	ENSP00000353731
ENST00000434918	ENSP00000402259
ENST00000416189	ENSP00000401359
ENST00000413651	ENSP00000410264
ENST00000491591
ENST00000490286
ENST00000494507
ENST00000468903
ENST00000497461
ENST00000461836

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004252	serine-type endopeptidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0008284	positive regulation of cell proliferation
GO:0010716	negative regulation of extracellular matrix disassembly
GO:0031295	T cell costimulation
GO:0033632	regulation of cell-cell adhesion mediated by integrin
GO:0042110	T cell activation
GO:0043542	endothelial cell migration

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0031258	lamellipodium membrane
GO:0045121	membrane raft
GO:0046581	intercellular canaliculus
GO:0070062	extracellular vesicular exosome
GO:0071438	invadopodium membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000035000

View Gene Order

Pathways

NETPATH

REACTOME

REACT_23824

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway

REACT_24019

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway

REACT_23974

Incretin synthesis, secretion, and inactivation pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.368912

RefSeq

NM_001935 XM_005246371

HUGO

OMIM

CCDS

CCDS2216

HPRD

02187

IMGT

EMBL

GenPept

RNA Seq Atlas