InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-F

Summary

InnateDB Gene

IDBG-73753.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-F

Gene Name

major histocompatibility complex, class I, F

Synonyms

CDA12; HLA-5.4; HLA-CDA12; HLAF

Species

Homo sapiens

Ensembl Gene

ENSG00000204642

Encoded Proteins

IDBP-73755

major histocompatibility complex, class I, F

IDBP-73757

major histocompatibility complex, class I, F

IDBP-73759

major histocompatibility complex, class I, F

IDBP-367652

major histocompatibility complex, class I, F

IDBP-367689

major histocompatibility complex, class I, F

IDBP-367713

major histocompatibility complex, class I, F

IDBP-367721

major histocompatibility complex, class I, F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:29722775-29738528

Strand

Forward strand

Band

p22.1

Transcripts

ENST00000376861	ENSP00000366057
ENST00000259951	ENSP00000259951
ENST00000334668	ENSP00000334263
ENST00000414333	ENSP00000389590
ENST00000434407	ENSP00000397376
ENST00000429294	ENSP00000416998
ENST00000444621	ENSP00000392251
ENST00000462777
ENST00000489502
ENST00000482257
ENST00000486194
ENST00000485513
ENST00000484704
ENST00000465459
ENST00000475996
ENST00000606273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042605	peptide antigen binding
GO:0046978	TAP1 binding
GO:0046979	TAP2 binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0019882	antigen processing and presentation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0050776	regulation of immune response
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane
GO:0042612	MHC class I protein complex
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane