InnateDB Protein
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IDBP-367689.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HLA-F
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Protein Name
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major histocompatibility complex, class I, F
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Synonyms
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CDA12; HLA-5.4; HLA-CDA12; HLAF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000397376
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InnateDB Gene
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IDBG-73753 (HLA-F)
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Protein Structure
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Function |
Involved in the presentation of foreign antigens to the immune system.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001916
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positive regulation of T cell mediated cytotoxicity
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0002480
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
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GO:0006955
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immune response
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0019882
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antigen processing and presentation
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0050776
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regulation of immune response
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GO:0060333
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interferon-gamma-mediated signaling pathway
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GO:0060337
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type I interferon signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR001039
MHC class I alpha chain, alpha1 alpha2 domains
IPR011162
MHC classes I/II-like antigen recognition protein
IPR027648
MHC class I alpha chain
|
PFAM |
PF00129
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PRINTS |
PR01638
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P30511
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PhosphoSite |
PhosphoSite-P30511
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TrEMBL |
O78094
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UniProt Splice Variant |
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Entrez Gene |
3134
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UniGene |
|
RefSeq |
NP_001091948
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HUGO |
HGNC:4963
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OMIM |
143110
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CCDS |
CCDS43439
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HPRD |
00884
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IMGT |
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EMBL |
AB011820
AF055066
AF523284
AF523285
AF523286
AF523287
AF523288
AF523289
AF523290
AF523291
AF523292
AF523293
AF523294
AF523295
AF523296
AF523297
AL022723
AL645939
AL669813
AL844851
AY253269
AY253270
AY253271
AY645742
AY645743
AY645744
AY645745
AY645746
AY645748
AY645749
AY645750
AY645751
AY645752
AY645753
AY645754
AY645756
AY645757
AY645758
AY645759
BA000025
BC009260
BC062991
BX005428
BX927250
CH471081
CR753818
DQ367723
X17093
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GenPept |
AAC24827
AAH09260
AAH62991
AAM74979
AAM74980
AAM74981
AAM74982
AAM74983
AAM74984
AAM74985
AAM74986
AAM74987
AAM74988
AAM74989
AAM74990
AAM74991
AAM74992
AAO86773
AAO86774
AAO86775
AAT73225
AAT73226
AAT73227
AAT73228
AAT73229
AAT73231
AAT73232
AAT73233
AAT73234
AAT73235
AAT73236
AAT73237
AAT73239
AAT73240
AAT73241
AAT73242
ABD38924
BAA32747
BAB63337
CAA34947
CAB46623
CAI17626
CAI17627
CAI18086
CAI18087
CAI18088
CAI18576
CAI18577
CAI18731
CAI18732
CAQ08349
CAQ08350
CAQ10721
CAQ10722
EAX03223
EAX03226
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