InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNH7

Summary

InnateDB Gene

IDBG-73789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH7

Gene Name

potassium voltage-gated channel, subfamily H (eag-related), member 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000184611

Encoded Proteins

IDBP-73791

potassium voltage-gated channel, subfamily H (eag-related), member 7

IDBP-73793

potassium voltage-gated channel, subfamily H (eag-related), member 7

IDBP-813756

potassium voltage-gated channel, subfamily H (eag-related), member 7

IDBP-813757

potassium voltage-gated channel, subfamily H (eag-related), member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:162371407-162838730

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000332142	ENSP00000331727
ENST00000328032	ENSP00000333781
ENST00000477019
ENST00000621889	ENSP00000483158
ENST00000618399	ENSP00000482818

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005242	inward rectifier potassium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007623	circadian rhythm
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0051291	protein heterooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059742

View Gene Order

ENSBTAG00000001899

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9NS40

TrEMBL

UniProt Splice Variant

Entrez Gene

90134

UniGene

Hs.599997 Hs.657413

RefSeq

NM_173162 NM_033272

HUGO

HGNC:18863

OMIM

608169

CCDS

CCDS2220 CCDS2219

HPRD

16295

IMGT

EMBL

AC007740 AC010876 AC104822 AF032897 BC035815

GenPept

AAD01946 AAH35815 AAX93139 AAX93153 AAY24106

RNA Seq Atlas

90134