Homo sapiens Gene: RPN2
Summary
InnateDB Gene IDBG-73849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPN2
Gene Name ribophorin II
Synonyms RIBIIR; RPN-II; RPNII; SWP1;
Species Homo sapiens
Ensembl Gene ENSG00000118705
Encoded Proteins
ribophorin II
ribophorin II
ribophorin II
ribophorin II
ribophorin II
ribophorin II
ribophorin II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:37178410-37241623
Strand Forward strand
Band q11.23
Transcripts
ENST00000237530 ENSP00000237530
ENST00000373632 ENSP00000362735
ENST00000373622 ENSP00000362724
ENST00000456102 ENSP00000399137
ENST00000437329 ENSP00000409580
ENST00000456400 ENSP00000399404
ENST00000462163 ENSP00000435563
ENST00000470352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006464 cellular protein modification process
GO:0006487 protein N-linked glycosylation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0007568 aging
GO:0010467 gene expression
GO:0018279 protein N-linked glycosylation via asparagine
GO:0042493 response to drug
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SRP-dependent cotranslational protein targeting to membrane pathway
Post-translational protein modification pathway
Translation pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Gene Expression pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Proteasome complex [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370895
RefSeq NM_001135771 NM_002951
HUGO
OMIM
CCDS CCDS13291 CCDS46599
HPRD 01609
IMGT
EMBL
GenPept
RNA Seq Atlas