Homo sapiens Gene: UPK2
Summary
InnateDB Gene IDBG-74102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPK2
Gene Name uroplakin 2
Synonyms UP2; UPII;
Species Homo sapiens
Ensembl Gene ENSG00000110375
Encoded Proteins
uroplakin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:118925164-118958559
Strand Forward strand
Band q23.3
Transcripts
ENST00000264031 ENSP00000264031
ENST00000534788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007275 multicellular organismal development
GO:0030855 epithelial cell differentiation
GO:0061024 membrane organization
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016324 apical plasma membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O00526
TrEMBL Q9UEE8
UniProt Splice Variant
Entrez Gene 7379
UniGene
RefSeq NM_006760
HUGO HGNC:12579
OMIM 611558
CCDS CCDS8404
HPRD
IMGT
EMBL AB009454 AB078607 AF000562 AY455312 BC113900 EF445028 Y13645
GenPept AAB58416 AAI13901 AAR19396 ACA06070 BAA23884 BAB84089 CAA73996
RNA Seq Atlas 7379