InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UPK2

Summary

InnateDB Protein

IDBP-74104.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPK2

Protein Name

uroplakin 2

Synonyms

UP2; UPII;

Species

Homo sapiens

Ensembl Protein

ENSP00000264031

InnateDB Gene

IDBG-74102 (UPK2)

Protein Structure

UniProt Annotation

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in ureter. {ECO:0000269PubMed:9846985}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007275	multicellular organismal development
GO:0030855	epithelial cell differentiation
GO:0061024	membrane organization

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016324	apical plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome