Version 5.4
Homo sapiens Gene: IGBP1
Summary
InnateDB Gene IDBG-74242.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGBP1
Gene Name immunoglobulin (CD79A) binding protein 1
Synonyms ALPHA-4; IBP1
Species Homo sapiens
Ensembl Gene ENSG00000089289
Encoded Proteins
IDBP-74244
immunoglobulin (CD79A) binding protein 1
IDBP-74246
immunoglobulin (CD79A) binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:70133449-70166324
Strand Forward strand
Band q13.1
Transcripts
ENST00000342206 ENSP00000363661
ENST00000356413 ENSP00000348784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 133 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 133 [view]
Protein-Protein 129 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
GO:0019904 protein domain specific binding
GO:0031434 mitogen-activated protein kinase kinase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0009966 regulation of signal transduction
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034612 response to tumor necrosis factor
GO:0035306 positive regulation of dephosphorylation
GO:0035308 negative regulation of protein dephosphorylation
GO:0042113 B cell activation
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060632 regulation of microtubule-based movement
GO:0070555 response to interleukin-1
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031221
View Gene Order
ENSBTAG00000007797
Not yet available
Pathways
NETPATH
NetPath_56
Prolactin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496267
RefSeq NM_001551
HUGO
OMIM
CCDS CCDS14396
HPRD 02140
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca